Symbol
Name
ID

Cbfb
core binding factor beta
MGI:99851

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Mouse Phenotypes

abnormal megakaryocyte differentiation

abnormal embryonic hematopoiesis

abnormal thymus morphology

abnormal thymus cell ratio

small thymus

thymus hypoplasia

decreased thymocyte number

enlarged spleen

abnormal definitive hematopoiesis

abnormal common myeloid progenitor cell morphology

abnormal erythropoiesis

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

abnormal T-helper 1 cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

abnormal double-positive T cell morphology

decreased double-positive T cell number

increased double-positive T cell number

abnormal myelopoiesis

extramedullary hematopoiesis

anemia

impaired hematopoiesis

abnormal megakaryocyte morphology

increased erythroid progenitor cell number

abnormal myeloblast morphology/development

decreased erythroblast number

thrombocytopenia

increased CD4-positive, alpha-beta T cell number

abnormal CD8-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

absent T cells

decreased lymphocyte cell number

increased leukocyte cell number

increased hematopoietic stem cell number

abnormal CD8-positive, alpha beta T cell morphology

abnormal spleen morphology

small spleen

spleen hypoplasia

abnormal splenic cell ratio

increased IgA level

increased IgE level

increased IgG1 level

increased immunoglobulin level

Availability

Mouse Genotype

Cbfb^tm1Spe/Cbfb^tm1Spe
Tg(Tek-GFP/Cbfb)1Spe/0

Cbfb^tm1Spe/Cbfb^tm1Spe
Tg(Tek-GFP/Cbfb)2Spe/0

Cbfb^tm1Spe/Cbfb^tm1Spe

Cbfb^tm1Tno/Cbfb^tm1Tno

Cbfb^tm1Tok/Cbfb^tm1Tok

Cbfb^tm1Tok/Cbfb^tm1Tok
Tg(Gata1-Cbfb)1Tok/0

Cbfb^tm2.1Spe/Cbfb^tm2.1Spe

Cbfb^tm1Ppl/Cbfb⁺

Cbfb^tm1Spe/Cbfb^tm2.1Spe

Cbfb^tm1Itan/Cbfb^tm1Itan
Tg(Lck-cre)1Cwi/0 (conditional)

Cbfb^tm1Itan/Cbfb^tm1Itan
Tg(Cd4-cre)1Cwi/0 (conditional)

Cbfb^tm1Lhc/Cbfb^tm1Lhc
Tg(Mx1-cre)1Cgn/0 (conditional)

Cbfb^tm1Lhc/Cbfb⁺
Tg(EIIa-cre)C5379Lmgd/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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